Urban Vitality

Community-based comprehensive lifestyle programs in patients with coronary artery disease: Objectives, design and expected results of Randomized Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists 2 trial (RESPONSE 2)

Article

<p>Patients with coronary artery disease (CAD) are at high risk of recurrent events. A healthy lifestyle can significantly reduce this risk. A previous trial, Randomized Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists (RESPONSE), demonstrated that nurse-coordinated outpatient clinics improve drug treatment of cardiovascular risk factors. However, lifestyle-related risk factors, including smoking, overweight, and physical inactivity, were common and remained largely unchanged at follow-up in most patients (66%). The aim of the current study is to evaluate the impact of 3 community-based lifestyle programs in patients after hospitalization for CAD. We are conducting a multicenter (n = 15), randomized trial that will recruit 800 patients to test the efficacy of up to 3 widely available commercial lifestyle programs, aimed at patients and their partners, on top of usual care. These programs are aimed at smoking cessation (Luchtsignaal(®)), weight loss (Weight Watchers(®)), and improving physical activity (Philips DirectLife(®)).</p><p><b>OUTCOMES</b>  The primary outcome at 12months is the proportion of patients in whom at least 1 lifestyle risk factor is improved without deterioration in any of the other 2, and a relative increase of at least 30% in this proportion is considered clinically relevant.</p>

Reference Lachman, S., Minneboo, M., Snaterse, M., Jorstad, H. T., ter Riet, G., Scholte Op Reimer, W. J., Boekholdt, S. M., Peters, R. J. G., & RESPONSE 2 study group (2015). Community-based comprehensive lifestyle programs in patients with coronary artery disease: Objectives, design and expected results of Randomized Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists 2 trial (RESPONSE 2). American Heart Journal, 170(2), 216-222. https://doi.org/10.1016/j.ahj.2015.05.010
Published by  Urban Vitality 1 August 2015

Publication date

Aug 2015

Author(s)

Sangeeta Lachman
Madelon Minneboo
Marjolein Snaterse
Harald T. Jorstad
Gerben ter Riet
Wilma J. Scholte Op Reimer
S. Matthijs Boekholdt
Ron J.G. Peters
RESPONSE 2 study group

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