Hogeschool van Amsterdam

Urban Vitality

Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study

Article

<b>Background: </b>A higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia.<br/><b>Objectives:</b> We explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (<i>n</i> = 1561).<br/><b>Methods:</b> Protein intake was assessed at year 2 by a Block foodfrequency questionnaire in participants (aged 70–79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear<br/>regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass.<br/><b>Results: </b>Mean (95% CI) protein intake was 0.90 (0.88, 0.92) g ·kg–1 · d–1 and mean (95% CI) 5-y change in muscle CSA was −9.8 (−10.6, −8.9) cm2. No association was observed between energyadjusted total (β = −0.00; 95% CI: −0.06, 0.06 cm2; P = 0.982), animal (β = −0.00; 95% CI: −0.06, 0.05 cm2; P = 0.923), or plant<br/>(β = +0.07; 95% CI: −0.06, 0.21 cm2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders.<br/><b>Conclusions:</b> This study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in midthigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.

Reference Verreijen, A. M., Engberink, M. F., Houston, D. K., Brouwer, I. A., Cawthon, P. M., Newman, A. B., Tylavsky, F. A., Harris, T. B., Weijs, P. JM., & Visser, M. (2019). Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study. The American Journal of Clinical Nutrition, 109(3), 535-543. https://doi.org/10.1093/ajcn/nqy341
Published by  Urban Vitality 1 March 2019

Publication date

Mar 2019

Author(s)

Denise K Houston
Ingeborg A Brouwer
Peggy M Cawthon
Ann B Newman
Frances A Tylavsky
Tamara B Harris
Marjolein Visser

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